Insulin Overdose

Non-Fatal Amlodipine and Insulin Overdose in an Elderly Person

Management of intentional overdose of insulin glargine.

nsulin overdose with more than 1000 units of glargine is ncommon and prolonged support, beyond the serum half ife for glargine is usually required. Glargine is a long-acting nsulin with low aqueous solubility at neutral pH.1 Following ubcutaneous (s.c.) injection, the solution forms microrecipitates that slowly release monomers and dimers. ecline in serum glucose begins by 1 h. Full activity is...

Intentional overdose with insulin: prognostic factors and toxicokinetic/toxicodynamic profiles

INTRODUCTION Prognostic factors in intentional insulin self-poisoning and the significance of plasma insulin levels are unclear. We therefore conducted this study to investigate prognostic factors in insulin poisoning, in relation to the value of plasma insulin concentration. METHODS We conducted a prospective study, and used logistic regression to explore prognostic factors and modelling to ...

Massive Levemir (Long-Acting) Insulin Overdose: Case Report

A 52-year-old insulin-dependant diabetic man presented to the Emergency Department 2 hours after a deliberate massive overdose of 2100 units of long-acting Levemir insulin and a large quantity of whisky. On initial assessment, his GCS was 3/15 and his capillary blood sugar was 2.6 mmol/L. The patient was given a 50 ml bolus of 50% dextrose, followed by intravenous infusions of both 5% and 10% d...

Acute pulmonary edema caused by hypoglycemia due to insulin overdose.

We report a very rare case of acute pulmonary edema caused by hypoglycemia from insulin overdose during an attempted suicide. A 16-year-old woman with type 1 diabetes was brought to our hospital because of hypoglycemic coma. She exhibited severe hypoxia; upon intubation, bloody froth poured out of the tube. Chest X-ray revealed bilateral infiltrates. Endocrinological data revealed high concentr...